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Health
Pharmacology
Pharmacology of kratom Th Pharmacology of kratom includes 54 different alkaloids. These comprise speciociliatine, paynantheine, corynantheidine, mitragynine, 7-hydroxymitragynine (7-HMG), mitraphylline, rhynchophylline, mitralactonal, raubasine, and mitragynaline. Many of the complex effects of kratom are attributed to the alkaloids mitragynine and 7-hydroxymitragynine, however other alkaloids may also work in concert with one another. With minimal affinity for the κ-opioid receptor, mitragynine and 7-HMG function as competitive antagonists of the δ-opioid receptor and partial agonists of the μ-opioid receptor. Compared to mitragynine, 7-HMG seems to have a greater affinity for the μ-opioid receptor. These substances exhibit functional selectivity and do not trigger the...
What does it feel like
Kratom, a natural herbal supplement derived from the leaves of the Mitragyna speciosa tree, can elicit a variety of sensations when consumed. Many individuals describe the experience as unique and multifaceted. Depending on the dosage and strain, kratom can induce feelings of relaxation, mild euphoria, and increased alertness. Users often report a sense of heightened focus and reduced fatigue. It's important to note that the effects of kratom can vary from person to person, and some may also experience a sense of tranquility and relief. According to Albert Garcia-Romeu, Ph.D., instructor of psychiatry and behavioral sciences at the Johns Hopkins...
Food and Drug Administration assessment
Food and Drug Administration assessment of Kratom The FDA's assessment of kratom has been characterized by a series of concerns and regulatory actions aimed at addressing potential health risks associated with this botanical substance. In April 2019, the FDA issued a statement emphasizing that kratom had not received approval for any medical use. The agency raised concerns about the safety of kratom products available in the United States and continued to enforce an import alert, which allowed the confiscation of imported kratom supplies. This move underscored the FDA's commitment to ensuring the safety of products containing kratom that enter the...
Drug tests
Will That Kratom Latte Cost You Your Job? Let’s Talk Drug Tests. Picture this: you’re sipping on your favorite kratom tea, feeling like a productivity wizard, when suddenly—gasp—your boss announces a surprise drug test. Panic sets in. Does kratom show up on a drug test? Will your herbal habit land you in hot water? Don’t worry, we’ve got the scoop. Spoiler alert: it’s not as straightforward as you might think. In this article, we’ll dive into the nitty-gritty of kratom and drug tests, from urine screens to hair follicles, and why your metabolism might be your best friend (or worst...
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